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Monitor Carefully (one)mitotane decreases levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Mitotane is actually a strong inducer of cytochrome P-4503A4; keep an eye on when coadministered with CYP3A4 substrates for probable dosage adjustments.By clicking deliver, you accept that you've got permission